Novel acetylcysteine regimens for treatment of paracetamol overdose
نویسندگان
چکیده
منابع مشابه
Impact of Amending the Acetylcysteine Marketing Authorisation on Treatment of Paracetamol Overdose
In September 2012, the Medicines and Healthcare products Regulatory Agency (MHRA) substantially amended the Marketing Authorisation for acetylcysteine following an extensive review. The present study examined the impact of this license change on patterns of acetylcysteine use in patients presenting to hospital after paracetamol (acetaminophen) overdose. Between September 2011 and April 2013, 78...
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BACKGROUND Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world. Paracetamol is commonly taken in overdose either deliberately or unintentionally. In high-income countries, paracetamol toxicity is a common cause of acute liver injury. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. These inter...
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Background: Acute opioid overdose is a common cause of admission in emergency department. In spite of the fact that naloxone is the main therapy for decades, there are controversies about the proper way of its use. This study aimed to compare two most recommended administration modes for naloxone. Methods: In this single-blind clinical trial, 80 patients with methadone overdose syndrome were...
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INTRODUCTION Paracetamol overdose is the most common drug overdose worldwide. To our knowledge, the maximum number of paracetamol tablets ingested reported in the literature is 45 g. CLINICAL PICTURE We describe a 21-year-old patient who acutely ingested 120 tablets, each 500 mg paracetamol (i.e., 60 g equivalent to 1200 mg/kg body weight) in a suicidal attempt. Our patient also drank 2 bottl...
متن کاملLiver transplantation after paracetamol overdose.
OBJECTIVE To evaluate the role of liver transplantation after paracetamol overdose. DESIGN Prospective study of consecutive candidates for transplantation and performance of transplantation over 18 months. SETTING Liver unit, King's College Hospital, London. MAIN OUTCOME MEASURES Fulfilment of indicators of poor prognosis, selection for transplantation, transplantation, survival. RESULT...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Drug Safety
سال: 2012
ISSN: 2042-0986,2042-0994
DOI: 10.1177/2042098612464265